| Title |
Blueberry as a Potential Radiosensitizer for Treating Cervical Cancer
|
|---|---|
| Published in |
Pathology & Oncology Research, September 2017
|
| DOI | 10.1007/s12253-017-0319-y |
| Pubmed ID | |
| Authors |
Kristoffer T. Davidson, Ziwen Zhu, Qian Bai, Huaping Xiao, Mark R. Wakefield, Yujiang Fang |
| Abstract |
Cervical cancer (CC) is a leading cause of death in women worldwide. Radiation therapy (RT) for CC is an effective alternative, but its toxicity remains challenging. Blueberry is amongst the most commonly consumed berries in the United States. We previously showed that resveratrol, a compound in red grapes, can be used as a radiosensitizer for prostate cancer. In this study, we found that the percentage of colonies, PCNA expression level and the OD value of cells from the CC cell line SiHa were all decreased in RT/Blueberry Extract (BE) group when compared to those in the RT alone group. Furthermore, TUNEL+ cells and the relative caspase-3 activity in the CC cells were increased in the RT/BE group compared to those in the RT alone group. The anti-proliferative effect of RT/BE on cancer cells correlated with downregulation of pro-proliferative molecules cyclin D and cyclin E. The pro-apoptotic effect of RT/BE correlated with upregulation of the pro-apoptotic molecule TRAIL. Thus, BE sensitizes SiHa cells to RT by inhibition of proliferation and promotion of apoptosis, suggesting that blueberry might be used as a potential radiosensitizer to treat CC. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 29% |
| United States | 3 | 14% |
| Australia | 1 | 5% |
| Ireland | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 9 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 52% |
| Practitioners (doctors, other healthcare professionals) | 8 | 38% |
| Scientists | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 21% |
| Student > Bachelor | 4 | 14% |
| Other | 2 | 7% |
| Professor > Associate Professor | 2 | 7% |
| Student > Ph. D. Student | 2 | 7% |
| Other | 4 | 14% |
| Unknown | 9 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 24% |
| Agricultural and Biological Sciences | 4 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
| Chemical Engineering | 1 | 3% |
| Environmental Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 12 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2024.
All research outputs
#724,004
of 25,410,626 outputs
Outputs from Pathology & Oncology Research
#2
of 782 outputs
Outputs of similar age
#15,213
of 330,623 outputs
Outputs of similar age from Pathology & Oncology Research
#1
of 24 outputs
Altmetric has tracked 25,410,626 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 782 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,623 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.