| Title |
Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry
|
|---|---|
| Published in |
The AAPS Journal, January 2015
|
| DOI | 10.1208/s12248-014-9710-8 |
| Pubmed ID | |
| Authors |
Jessica R. McCombs, Shawn C. Owen |
| Abstract |
Antibody drug conjugates (ADCs) have emerged as an important pharmaceutical class of drugs designed to harness the specificity of antibodies with the potency of small molecule therapeutics. The three main components of ADCs are the antibody, the linker, and the payload; the majority of early work focused intensely on improving the functionality of these pieces. Recently, considerable attention has been focused on developing methods to control the site and number of linker/drug conjugated to the antibody, with the aim of producing more homogenous ADCs. In this article, we review popular conjugation methods and highlight recent approaches including "click" conjugation and enzymatic ligation. We discuss current linker technology, contrasting the characteristics of cleavable and non-cleavable linkers, and summarize the essential properties of ADC payload, centering on chemotherapeutics. In addition, we report on the progress in characterizing to determine physicochemical properties and on advances in purifying to obtain homogenous products. Establishing a set of selection and analytical criteria will facilitate the translation of novel ADCs and ensure the production of effective biosimilars. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 60% |
| Korea, Republic of | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 595 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | <1% |
| United States | 2 | <1% |
| France | 1 | <1% |
| Sri Lanka | 1 | <1% |
| Italy | 1 | <1% |
| Denmark | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 584 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 112 | 19% |
| Researcher | 96 | 16% |
| Student > Bachelor | 81 | 14% |
| Student > Master | 66 | 11% |
| Other | 27 | 5% |
| Other | 70 | 12% |
| Unknown | 143 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 139 | 23% |
| Biochemistry, Genetics and Molecular Biology | 93 | 16% |
| Agricultural and Biological Sciences | 68 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 50 | 8% |
| Medicine and Dentistry | 20 | 3% |
| Other | 75 | 13% |
| Unknown | 150 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2024.
All research outputs
#1,312,917
of 25,605,018 outputs
Outputs from The AAPS Journal
#25
of 1,464 outputs
Outputs of similar age
#17,562
of 360,884 outputs
Outputs of similar age from The AAPS Journal
#2
of 27 outputs
Altmetric has tracked 25,605,018 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,464 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,884 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.