Title |
Studies on lung N-methyltransferases, a pharmacological approach
|
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Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, September 1980
|
DOI | 10.1007/bf00505743 |
Pubmed ID | |
Authors |
Robert G. Pendleton, George Gessner, John Sawyer |
Abstract |
Phenylethanolamine N-methyltransferase (PNMT) was identified as the primary, high affinity N-methylating enzyme for phenylethanolamine (PEA) in rat, dog and Rhesus monkey lung. Human and rabbit lung, however, do not contain this enzyme but possess a more non-specific or general N-methyltransferase with a relatively low affinity for PEA and for which beta-phenethylamine (beta-PE) is also a substrate. The former but not the latter enzyme is markedly inhibited by micromolar concentrations of the PNMT antagonist, SK & F 64139. This evidence indicates that certain species differences exist for the enzyme system(s) available for the N-methylation of phenethylamine-type compounds in pulmonary tissue. |
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