| Title |
Pharmacokinetics of parenteral and oral melperone in man
|
|---|---|
| Published in |
European Journal of Clinical Pharmacology, March 1982
|
| DOI | 10.1007/bf00545974 |
| Pubmed ID | |
| Authors |
L. Borgström, H. Larsson, L. Molander |
| Abstract |
The pharmacokinetics of melperone (Buronil, Ferrosan, Sweden) was studied after administration of various parenteral and oral doses to man. After parenteral administration, the data could be fitted to a two-compartment model, but after oral dosing the distribution phase could not be separated from the elimination phase, and so an one-compartment model gave the best fit. The half-lives were about 3-4 h, except after intramuscular injection, when the half-life was about 6 h. The bioavailability of oral doses was about 60% of the intravenous injection. After the highest oral dose of 100 mg, the pharmacokinetics, expressed as AUC or Cmax, showed non-linearity, possibly due to saturation of the hepatic elimination system. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 33% |
| Student > Master | 2 | 33% |
| Unknown | 2 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 17% |
| Agricultural and Biological Sciences | 1 | 17% |
| Physics and Astronomy | 1 | 17% |
| Chemistry | 1 | 17% |
| Unknown | 2 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2021.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from European Journal of Clinical Pharmacology
#951
of 2,744 outputs
Outputs of similar age
#1,992
of 7,246 outputs
Outputs of similar age from European Journal of Clinical Pharmacology
#2
of 4 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,744 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
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