| Title |
Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer’s disease: an updated meta-analysis
|
|---|---|
| Published in |
Journal of Neural Transmission, February 2009
|
| DOI | 10.1007/s00702-009-0189-x |
| Pubmed ID | |
| Authors |
Bai-song Wang, Hao Wang, Zhao-hui Wei, Yan-yan Song, Lu Zhang, Hong-zhuan Chen |
| Abstract |
The objective of this study was to provide an updated meta-analysis of the efficacy and safety of huperzine A (HupA) in Alzheimer's disease (AD). We searched for randomized trials comparing HupA with placebo in the treatment of AD. The primary outcome measures were mini-mental state examination (MMSE) and activities of daily living scale (ADL). Data were extracted from four randomized clinical trials and analyzed using standard meta-analysis and meta-regression methods. Oral administration of HupA for 8-24 weeks (300-500 microg daily) led to significant improvements in MMSE and ADL. The results of meta-regression showed that the estimated effect size of MMSE and ADL was increased over the treatment time. Most adverse events were cholinergic in nature and no serious adverse events occurred. Huperzine A is a well-tolerated drug that could significantly improve cognitive performance and ADL in patients with AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Unknown | 122 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 11% |
| Student > Postgraduate | 13 | 10% |
| Student > Ph. D. Student | 13 | 10% |
| Researcher | 12 | 10% |
| Student > Bachelor | 11 | 9% |
| Other | 23 | 18% |
| Unknown | 39 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 16% |
| Agricultural and Biological Sciences | 14 | 11% |
| Psychology | 11 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 7% |
| Chemistry | 7 | 6% |
| Other | 21 | 17% |
| Unknown | 43 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2023.
All research outputs
#4,806,377
of 23,578,176 outputs
Outputs from Journal of Neural Transmission
#448
of 1,816 outputs
Outputs of similar age
#18,118
of 95,514 outputs
Outputs of similar age from Journal of Neural Transmission
#1
of 11 outputs
Altmetric has tracked 23,578,176 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,816 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,514 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.