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Mendeley readers
Attention Score in Context
| Title |
Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry Letters, November 2014
|
| DOI | 10.1016/j.bmcl.2014.11.004 |
| Pubmed ID | |
| Authors |
Mirco Zeiger, Sebastian Stark, Elisabeth Kalden, Bettina Ackermann, Jan Ferner, Ute Scheffer, Fatemeh Shoja-Bazargani, Veysel Erdel, Harald Schwalbe, Michael W. Göbel |
| Abstract |
Basic molecular building blocks such as benzene rings, amidines, guanidines, and amino groups have been combined in a systematic way to generate ligand candidates for HIV-1 TAR RNA. Ranking of the resulting compounds was achieved in a fluorimetric Tat-TAR competition assay. Although simple molecules such as phenylguanidine are inactive, few iteration steps led to a set of ligands with IC50 values ranging from 40 to 150 μM. 1,7-Diaminoisoquinoline 17 and 2,4,6-triaminoquinazoline 22 have been further characterized by NMR titrations with TAR RNA. Compound 22 is bound to TAR at two high affinity sites and shows slow exchange between the free ligand and the RNA complex. These results encourage investigations of dimeric ligands built from two copies of compound 22 or related heterocycles. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 30% |
| Student > Master | 7 | 14% |
| Student > Bachelor | 5 | 10% |
| Researcher | 5 | 10% |
| Professor > Associate Professor | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 14 | 28% |
| Biochemistry, Genetics and Molecular Biology | 8 | 16% |
| Agricultural and Biological Sciences | 8 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Medicine and Dentistry | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 13 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2015.
All research outputs
#4,807,882
of 25,374,647 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#2,213
of 13,778 outputs
Outputs of similar age
#52,500
of 276,320 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#11
of 133 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,778 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,320 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.