| Title |
The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen
|
|---|---|
| Published in |
Psychopharmacology, February 2010
|
| DOI | 10.1007/s00213-010-1784-0 |
| Pubmed ID | |
| Authors |
Clinton E. Canal, Uade B. Olaghere da Silva, Paul J. Gresch, Erin E. Watt, Elaine Sanders-Bush, David C. Airey |
| Abstract |
Hallucinogenic serotonin 2A (5-HT(2A)) receptor partial agonists, such as (+ or -)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), induce a frontal cortex-dependent head-twitch response (HTR) in rodents, a behavioral proxy of a hallucinogenic response that is blocked by 5-HT(2A) receptor antagonists. In addition to 5-HT(2A) receptors, DOI and most other serotonin-like hallucinogens have high affinity and potency as partial agonists at 5-HT(2C) receptors. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Italy | 1 | 1% |
| Unknown | 64 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 16% |
| Student > Bachelor | 11 | 16% |
| Researcher | 10 | 15% |
| Student > Doctoral Student | 5 | 7% |
| Other | 4 | 6% |
| Other | 8 | 12% |
| Unknown | 19 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 18 | 26% |
| Agricultural and Biological Sciences | 11 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Psychology | 4 | 6% |
| Other | 7 | 10% |
| Unknown | 19 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2016.
All research outputs
#8,495,660
of 25,342,911 outputs
Outputs from Psychopharmacology
#2,296
of 5,653 outputs
Outputs of similar age
#37,609
of 100,678 outputs
Outputs of similar age from Psychopharmacology
#15
of 36 outputs
Altmetric has tracked 25,342,911 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,653 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,678 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.