Title |
Ofatumumab
|
---|---|
Published in |
Drugs, September 2012
|
DOI | 10.2165/11203850-000000000-00000 |
Pubmed ID | |
Authors |
Mark Sanford, Paul L. McCormack |
Abstract |
Ofatumumab is a fully human anti-CD20 monoclonal antibody that induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity in CD20-expressing B lymphocytes. Ofatumumab is highly potent in lysing B cells, and this appears to stem from its binding site on the short extracellular loop of the target CD20 protein and its slow release from the target molecule. In a pivotal, noncomparative study in patients with fludarabine- and alemtuzumab-refractory chronic lymphocytic leukaemia (CLL), ofatumumab induced objective responses in 58% (99% CI 40, 74) of patients, which met a prespecified superiority criterion. The median duration of response was 7.1 months. The median progression-free survival was 5.7 months and the median overall survival was 13.7 months. In patients with fludarabine- and alemtuzumab-refractory CLL, infections and neutropenia were the most frequent treatment-related adverse events (all grades) that occurred during ofatumumab treatment; infections that commenced during treatment led to death in five patients (8%). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 10% |
Unknown | 9 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 20% |
Other | 1 | 10% |
Student > Doctoral Student | 1 | 10% |
Student > Bachelor | 1 | 10% |
Student > Master | 1 | 10% |
Other | 2 | 20% |
Unknown | 2 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 60% |
Immunology and Microbiology | 1 | 10% |
Agricultural and Biological Sciences | 1 | 10% |
Unknown | 2 | 20% |