| Title |
Transforming growth factor beta induced (TGFBI) is a potential signature gene for mesenchymal subtype high-grade glioma
|
|---|---|
| Published in |
Journal of Neuro-Oncology, January 2018
|
| DOI | 10.1007/s11060-017-2729-9 |
| Pubmed ID | |
| Authors |
Yuan-Bo Pan, Chi-Hao Zhang, Si-Qi Wang, Peng-Hui Ai, Kui Chen, Liang Zhu, Zhao-Liang Sun, Dong-Fu Feng |
| Abstract |
Previous study revealed that higher expression of transforming growth factor beta induced (TGFBI) is correlated to poorer cancer-specific survival and higher proportion of tumor necrosis and Fuhrman grades III and IV in clear cell renal cell carcinomas. However, the relationships between TGFBI expression and malignant phenotypes of gliomas remain unclear. We downloaded and analyzed data from seven GEO datasets (GSE68848, GSE4290, GSE13041, GSE4271, GSE83300, GSE34824 and GSE84010), the TCGA database and the REMBRANDT database to investigate whether TGFBI could be a biomarker of glioma. From microarray data (GSE68848, GSE4290) and RNA-seq data (TCGA), TGFBI expression levels were observed to correlate positively with pathological grade, and TGFBI expression levels were significantly higher in gliomas than in normal brain tissues. Furthermore, in GSE13041, GSE4271 and the TCGA cohort, TGFBI expression in the mesenchymal (Mes) subtype high-grade glioma (HGG) was significantly higher than that in the proneural subtype. Kaplan-Meier survival analysis of GBM patients in the GSE83300 dataset, REMBRANDT and TCGA cohort revealed that patients in the top 50% TGFBI expression group survived for markedly shorter periods than those in the bottom 50%. Analysis of grade III gliomas showed that the median survival time was significantly shorter in the TGFBI high expression group than in the TGFBI low expression group. In addition, we found that TGFBI expression levels might relate to several classical molecular characterizations of glioma, such as, IDH mutation, TP53 mutation, EGFR amplification, etc. These results suggest that TGFBI expression positively correlates with glioma pathological grades and that TGFBI is a potential signature gene for Mes subtype HGG and a potential prognostic molecule. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 31% |
| Student > Ph. D. Student | 5 | 19% |
| Student > Bachelor | 3 | 12% |
| Professor | 2 | 8% |
| Student > Doctoral Student | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 23% |
| Immunology and Microbiology | 5 | 19% |
| Neuroscience | 4 | 15% |
| Engineering | 3 | 12% |
| Medicine and Dentistry | 2 | 8% |
| Other | 0 | 0% |
| Unknown | 6 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2019.
All research outputs
#15,487,739
of 23,015,156 outputs
Outputs from Journal of Neuro-Oncology
#1,972
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Outputs of similar age
#269,745
of 442,119 outputs
Outputs of similar age from Journal of Neuro-Oncology
#56
of 117 outputs
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