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有害事象自発報告データベース(JADER)を用いた一般用医薬品の総合感冒剤による有害事象プロファイルの検討

Overview of attention for article published in Yakugaku Zasshi = Journal of Pharmaceutical Society of Japan, January 2018
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Title
有害事象自発報告データベース(JADER)を用いた一般用医薬品の総合感冒剤による有害事象プロファイルの検討
Published in
Yakugaku Zasshi = Journal of Pharmaceutical Society of Japan, January 2018
DOI 10.1248/yakushi.17-00172
Pubmed ID
Authors

Sayaka Sasaoka, Haruna Hatahira, Shiori Hasegawa, Yumi Motooka, Akiho Fukuda, Misa Naganuma, Ryogo Umetsu, Satoshi Nakao, Akari Shimauchi, Natsumi Ueda, Kouseki Hirade, Kazuhiro Iguchi, Mitsuhiro Nakamura

Abstract

 OTC combination cold remedies are widely used in Japan. In the present study, we aimed to evaluate the adverse event profiles of OTC combination cold remedy based on the components using the Japanese Adverse Drug Event Report (JADER) database. The JADER database contained 430587 reports between April 2004 and November 2016. 1084 adverse events associated with the use of OTC combination cold remedy were reported. Reporting odds ratio (ROR) was used to detect safety signals. The ROR values for "skin and subcutaneous tissue disorders", "hepatobiliary disorders", and "immune system disorders" stratified by system organ class of the Medical Dictionary for Regulatory Activities (MedDRA) were 9.82 (8.71-11.06), 2.63 (2.25-3.07), and 3.13 (2.63-3.74), respectively. OTC combination cold remedy containing acetaminophen exhibited a significantly higher reporting ratio for "hepatobiliary disorders" than OTC combination cold remedy without acetaminophen. We demonstrated the potential risk of OTC combination cold remedy in a real-life setting. Our results suggested that the monitoring of individuals using OTC combination cold remedy is important.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Lecturer > Senior Lecturer 1 11%
Other 1 11%
Lecturer 1 11%
Student > Bachelor 1 11%
Professor 1 11%
Other 3 33%
Unknown 1 11%
Readers by discipline Count As %
Medicine and Dentistry 3 33%
Pharmacology, Toxicology and Pharmaceutical Science 2 22%
Nursing and Health Professions 1 11%
Economics, Econometrics and Finance 1 11%
Engineering 1 11%
Other 0 0%
Unknown 1 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2018.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Yakugaku Zasshi = Journal of Pharmaceutical Society of Japan
#1,420
of 1,958 outputs
Outputs of similar age
#283,799
of 449,550 outputs
Outputs of similar age from Yakugaku Zasshi = Journal of Pharmaceutical Society of Japan
#8
of 14 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,958 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,550 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.