| Title |
Pharmacokinetics and Pharmacodynamics of Hydroxyurea
|
|---|---|
| Published in |
Clinical Pharmacokinetics, September 2012
|
| DOI | 10.2165/00003088-199834050-00002 |
| Pubmed ID | |
| Authors |
Peter R. Gwilt, William G. Tracewell |
| Abstract |
Hydroxyurea is used in the treatment of various forms of cancer, sickle-cell anaemia and HIV infection. Oral absorption of the drug is virtually complete, the volume of distribution is equivalent to total body water and elimination is through both renal and nonrenal mechanisms. Nonrenal elimination of hydroxyurea is characterised by Michaelis-Menten kinetics. Further studies are necessary to clarify several aspects of the pharmacokinetics and pharmacodynamics of hydroxyurea: the effect of age and disease state, concentration-effect relationship, the role of therapeutic drug monitoring, and the mechanisms of renal and nonrenal elimination. The recent development of improved assays for hydroxyurea should have benefits for future pharmacokinetic studies. |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 65 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 15% |
| Researcher | 9 | 13% |
| Student > Bachelor | 8 | 12% |
| Student > Master | 7 | 10% |
| Student > Doctoral Student | 5 | 7% |
| Other | 8 | 12% |
| Unknown | 20 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 19% |
| Medicine and Dentistry | 12 | 18% |
| Biochemistry, Genetics and Molecular Biology | 8 | 12% |
| Chemistry | 5 | 7% |
| Nursing and Health Professions | 3 | 4% |
| Other | 4 | 6% |
| Unknown | 22 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Clinical Pharmacokinetics
#682
of 1,602 outputs
Outputs of similar age
#64,139
of 187,180 outputs
Outputs of similar age from Clinical Pharmacokinetics
#233
of 450 outputs
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