| Title |
Carcinogenicity of deoxycholate, a secondary bile acid
|
|---|---|
| Published in |
Archives of Toxicology, January 2011
|
| DOI | 10.1007/s00204-011-0648-7 |
| Pubmed ID | |
| Authors |
Carol Bernstein, Hana Holubec, Achyut K. Bhattacharyya, Huy Nguyen, Claire M. Payne, Beryl Zaitlin, Harris Bernstein |
| Abstract |
High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be important in colon cancer etiology, this study investigated whether DOC, at a high physiologic level, could be a colon carcinogen. Addition of 0.2% DOC for 8-10 months to the diet of 18 wild-type mice induced colonic tumors in 17 mice, including 10 with cancers. Addition of the antioxidant chlorogenic acid at 0.007% to the DOC-supplemented diet significantly reduced tumor formation. These results indicate that a high fat diet in humans, associated with increased risk of colon cancer, may have its carcinogenic potential mediated through the action of bile acids, and that some dietary anti-oxidants may ameliorate this carcinogenicity. |
Mendeley readers
The data shown below were compiled from readership statistics for 219 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | <1% |
| Portugal | 1 | <1% |
| Unknown | 217 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 21% |
| Student > Bachelor | 30 | 14% |
| Researcher | 29 | 13% |
| Student > Master | 24 | 11% |
| Student > Doctoral Student | 17 | 8% |
| Other | 29 | 13% |
| Unknown | 44 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 45 | 21% |
| Agricultural and Biological Sciences | 41 | 19% |
| Medicine and Dentistry | 35 | 16% |
| Immunology and Microbiology | 14 | 6% |
| Chemistry | 11 | 5% |
| Other | 17 | 8% |
| Unknown | 56 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2024.
All research outputs
#7,708,493
of 23,445,423 outputs
Outputs from Archives of Toxicology
#982
of 2,671 outputs
Outputs of similar age
#56,575
of 185,876 outputs
Outputs of similar age from Archives of Toxicology
#10
of 16 outputs
Altmetric has tracked 23,445,423 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,671 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 185,876 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.