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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gut Homing Receptors on CD8 T Cells Are Retinoic Acid Dependent and Not Maintained by Liver Dendritic or Stellate Cells
|
|---|---|
| Published in |
Gastroenterology, February 2009
|
| DOI | 10.1053/j.gastro.2009.02.046 |
| Pubmed ID | |
| Authors |
Bertus Eksteen, J. Rodrigo Mora, Emma L. Haughton, Neil C. Henderson, Laura Lee–Turner, Eduardo J. Villablanca, Stuart M. Curbishley, Alex I. Aspinall, Ulrich H. von Andrian, David H. Adams |
| Abstract |
Lymphocytes primed by intestinal dendritic cells (DC) express the gut-homing receptors CCR9 and alpha4beta7, which recognize CCL25 and mucosal addressin cell-adhesion molecule-1 in the intestine promoting the development of regional immunity. In mice, imprinting of CCR9 and alpha4beta7 is dependent on retinoic acid during T-cell activation. Tissue specificity is lost in primary sclerosing cholangitis (PSC), an extraintestinal manifestation of inflammatory bowel disease, when ectopic expression of mucosal addressin cell-adhesion molecule-1 and CCL25 in the liver promotes recruitment of CCR9+alpha4beta7+ T cells to the liver. We investigated the processes that control enterohepatic T-cell migration and whether the ability to imprint CCR9 and alpha4beta7 is restricted to intestinal DCs or can under some circumstances be acquired by hepatic DCs in diseases such as PSC. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Netherlands | 1 | 1% |
| Italy | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 90 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 26% |
| Student > Ph. D. Student | 22 | 23% |
| Student > Master | 16 | 17% |
| Student > Postgraduate | 7 | 7% |
| Student > Bachelor | 6 | 6% |
| Other | 7 | 7% |
| Unknown | 13 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 33% |
| Agricultural and Biological Sciences | 20 | 21% |
| Immunology and Microbiology | 16 | 17% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Nursing and Health Professions | 1 | 1% |
| Other | 6 | 6% |
| Unknown | 13 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2021.
All research outputs
#7,960,512
of 25,374,647 outputs
Outputs from Gastroenterology
#5,632
of 12,315 outputs
Outputs of similar age
#36,687
of 109,488 outputs
Outputs of similar age from Gastroenterology
#28
of 54 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 12,315 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,488 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.