Title |
Gut Homing Receptors on CD8 T Cells Are Retinoic Acid Dependent and Not Maintained by Liver Dendritic or Stellate Cells
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Published in |
Gastroenterology, February 2009
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DOI | 10.1053/j.gastro.2009.02.046 |
Pubmed ID | |
Authors |
Bertus Eksteen, J. Rodrigo Mora, Emma L. Haughton, Neil C. Henderson, Laura Lee–Turner, Eduardo J. Villablanca, Stuart M. Curbishley, Alex I. Aspinall, Ulrich H. von Andrian, David H. Adams |
Abstract |
Lymphocytes primed by intestinal dendritic cells (DC) express the gut-homing receptors CCR9 and alpha4beta7, which recognize CCL25 and mucosal addressin cell-adhesion molecule-1 in the intestine promoting the development of regional immunity. In mice, imprinting of CCR9 and alpha4beta7 is dependent on retinoic acid during T-cell activation. Tissue specificity is lost in primary sclerosing cholangitis (PSC), an extraintestinal manifestation of inflammatory bowel disease, when ectopic expression of mucosal addressin cell-adhesion molecule-1 and CCL25 in the liver promotes recruitment of CCR9+alpha4beta7+ T cells to the liver. We investigated the processes that control enterohepatic T-cell migration and whether the ability to imprint CCR9 and alpha4beta7 is restricted to intestinal DCs or can under some circumstances be acquired by hepatic DCs in diseases such as PSC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 3% |
Netherlands | 1 | 1% |
Italy | 1 | 1% |
Germany | 1 | 1% |
Unknown | 90 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 25 | 26% |
Student > Ph. D. Student | 22 | 23% |
Student > Master | 16 | 17% |
Student > Postgraduate | 7 | 7% |
Student > Bachelor | 6 | 6% |
Other | 7 | 7% |
Unknown | 13 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 33% |
Agricultural and Biological Sciences | 20 | 21% |
Immunology and Microbiology | 16 | 17% |
Biochemistry, Genetics and Molecular Biology | 8 | 8% |
Nursing and Health Professions | 1 | 1% |
Other | 6 | 6% |
Unknown | 13 | 14% |