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Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes

Overview of attention for article published in Scientific Reports, January 2015
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Title
Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes
Published in
Scientific Reports, January 2015
DOI 10.1038/srep08113
Pubmed ID
Authors

Chao Liu, Jia Hu, Chunxiang Qu, Lin Wang, Guodong Huang, Pengfei Niu, Zhaomin Zhong, Fashui Hong, Guanghui Wang, John H. Postlethwait, Han Wang

Abstract

Cryptochromes function in animal circadian regulation. Zebrafish are known to have six cryptochrome (cry) genes but their evolutionary relationships are not yet fully resolved. Here, comparative genomic analyses revealed that a local duplication of ancestral chordate Cry occurred likely before the first round of vertebrate genome duplication (VGD); following two successive rounds of VGD and subsequent gene losses, coelacanths retained cry1a, cry1b, cry2 and cry3; and following the third-round teleost genome duplication (TGD) and subsequent gene losses, zebrafish retained six cry genes, renamed as cry1aa (zcry1a in the old nomenclature), cry1ab (zcry1b), cry1ba (zcry2a), cry1bb (zcry2b), cry2 (zcry3) and cry3 (zcry4). Molecular evolutionary analyses suggested that zebrafish cry genes have evolved divergent functions, which is further supported by their distinct and rhythmic expression patterns as shown by both in situ hybridization and quantitative real-time PCR. Systematic cell transfection assays divided six Cry proteins into repressive Cry1aa, Cry1ab, Cry1ba and Cry1bb, and non-repressive Cry2 and Cry3. Cry2 is non-repressive because it lacks an effective protein-protein interaction domain although it does possess a nuclear localization signal (NLS) motif, whilst Cry3 lacks both an NLS motif and a protein-protein interaction domain. These findings provide a better understanding of evolution of zebrafish cry genes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
China 1 1%
Australia 1 1%
Unknown 88 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 22%
Student > Bachelor 15 16%
Researcher 13 14%
Student > Master 8 9%
Student > Doctoral Student 5 5%
Other 12 13%
Unknown 18 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 31%
Agricultural and Biological Sciences 21 23%
Neuroscience 5 5%
Immunology and Microbiology 4 4%
Computer Science 2 2%
Other 9 10%
Unknown 22 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2015.
All research outputs
#20,251,039
of 22,780,165 outputs
Outputs from Scientific Reports
#105,044
of 122,965 outputs
Outputs of similar age
#297,227
of 353,551 outputs
Outputs of similar age from Scientific Reports
#1,026
of 1,202 outputs
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