↓ Skip to main content

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

Overview of attention for article published in Nature, January 2018
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

dimensions_citation
288 Dimensions

Readers on

mendeley
726 Mendeley
citeulike
4 CiteULike
Title
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells
Published in
Nature, January 2018
DOI 10.1038/nature25154
Pubmed ID
Authors

Juan I. Garaycoechea, Gerry P. Crossan, Frédéric Langevin, Lee Mulderrig, Sandra Louzada, Fentang Yang, Guillaume Guilbaud, Naomi Park, Sophie Roerink, Serena Nik-Zainal, Michael R. Stratton, Ketan J. Patel

Abstract

Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies. Here we describe the features and mutational landscape of DNA damage caused by acetaldehyde, an endogenous and alcohol-derived metabolite. This damage results in DNA double-stranded breaks that, despite stimulating recombination repair, also cause chromosome rearrangements. We combined transplantation of single haematopoietic stem cells with whole-genome sequencing to show that this damage occurs in stem cells, leading to deletions and rearrangements that are indicative of microhomology-mediated end-joining repair. Moreover, deletion of p53 completely rescues the survival of aldehyde-stressed and mutated haematopoietic stem cells, but does not change the pattern or the intensity of genome instability within individual stem cells. These findings characterize the mutation of the stem-cell genome by an alcohol-derived and endogenous source of DNA damage. Furthermore, we identify how the choice of DNA-repair pathway and a stringent p53 response limit the transmission of aldehyde-induced mutations in stem cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 1,313 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 726 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 726 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 145 20%
Researcher 127 17%
Student > Bachelor 92 13%
Student > Master 81 11%
Other 32 4%
Other 107 15%
Unknown 142 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 237 33%
Agricultural and Biological Sciences 119 16%
Medicine and Dentistry 79 11%
Chemistry 25 3%
Engineering 15 2%
Other 89 12%
Unknown 162 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2040. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2023.
All research outputs
#4,490
of 25,591,967 outputs
Outputs from Nature
#480
of 98,331 outputs
Outputs of similar age
#57
of 451,657 outputs
Outputs of similar age from Nature
#5
of 804 outputs
Altmetric has tracked 25,591,967 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,331 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 804 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.