| Title |
Strategies of Tumor Immune Evasion
|
|---|---|
| Published in |
BioDrugs, August 2012
|
| DOI | 10.2165/00063030-200519060-00002 |
| Pubmed ID | |
| Authors |
Barbara Seliger |
| Abstract |
During the last decade, increased understanding of the molecular mechanisms responsible for immune activation to protect against challenges by tumor cells has revolutionized the field of immunotherapy research. It has been demonstrated that the dysfunction of the host's immune system represents one of the major mechanisms by which tumors evade immunosurveillance. This is due, for example, to T cell anergy, the existence of regulatory T cells, and systemic defects of dendritic cells derived from tumor patients. In addition, escape from immunosurveillance can also be linked to tumor-related factors, including secretion of immunosuppressive cytokines, resistance to apoptosis, and deficient expression of immunomodulatory molecules and major histocompatibility complex (MHC) class I antigens possibly due to immunoselection. Both host- and tumor-related mechanisms can lead to a failure to mount a proper anti-tumor-specific immune response, and these are frequently key factors in limiting the success of cancer immunotherapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 139 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 36 | 25% |
| Student > Ph. D. Student | 24 | 17% |
| Student > Master | 20 | 14% |
| Researcher | 16 | 11% |
| Student > Doctoral Student | 8 | 6% |
| Other | 14 | 10% |
| Unknown | 25 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 24% |
| Biochemistry, Genetics and Molecular Biology | 31 | 22% |
| Medicine and Dentistry | 19 | 13% |
| Immunology and Microbiology | 7 | 5% |
| Chemistry | 6 | 4% |
| Other | 14 | 10% |
| Unknown | 32 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2023.
All research outputs
#3,135,502
of 25,371,288 outputs
Outputs from BioDrugs
#95
of 746 outputs
Outputs of similar age
#21,049
of 186,051 outputs
Outputs of similar age from BioDrugs
#22
of 257 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 746 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,051 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 257 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.