| Title |
Trans fatty acids and cardiovascular risk: A unique cardiometabolic imprint?
|
|---|---|
| Published in |
Current Atherosclerosis Reports, March 2008
|
| DOI | 10.1007/s11883-007-0065-9 |
| Pubmed ID | |
| Authors |
Dariush Mozaffarian, Walter C. Willett |
| Abstract |
Evidence from randomized controlled trials indicates that consumption of trans fatty acids (TFA) leads to harmful changes in serum lipids, systemic inflammation, endothelial function, and, in nonhuman primates, visceral adiposity and insulin resistance. Prospective observational studies demonstrate strong positive associations between TFA consumption and risk of myocardial infarction, coronary heart disease death, and sudden death. Links have also been seen between TFA intake and incidence of diabetes, adiposity, and other chronic conditions. The physiologic effects demonstrated in randomized trials suggest that TFA consumption produces a unique cardiometabolic imprint via pathways linked to the insulin resistance syndrome. The strength and consistency of the evidence for harmful effects of TFA, together with the feasibility of elimination of industrially produced TFA from foods, indicates little reason for continued use of partially hydrogenated oils containing TFA in food preparation and manufacturing. Consumer education regarding the sources and hazards of TFA, combined with voluntary or legislated adoption by restaurants and food manufacturers of alternatives to partially hydrogenated oils, could avert tens of thousands of coronary events each year in the United States and around the world. |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 2% |
| Australia | 1 | 2% |
| Unknown | 64 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 18% |
| Student > Bachelor | 10 | 15% |
| Researcher | 8 | 12% |
| Student > Master | 7 | 11% |
| Student > Doctoral Student | 5 | 8% |
| Other | 16 | 24% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 32% |
| Agricultural and Biological Sciences | 11 | 17% |
| Nursing and Health Professions | 10 | 15% |
| Biochemistry, Genetics and Molecular Biology | 8 | 12% |
| Chemistry | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 9 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2019.
All research outputs
#8,517,130
of 25,392,205 outputs
Outputs from Current Atherosclerosis Reports
#405
of 860 outputs
Outputs of similar age
#33,418
of 94,734 outputs
Outputs of similar age from Current Atherosclerosis Reports
#5
of 12 outputs
Altmetric has tracked 25,392,205 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 860 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,734 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.