| Title |
One hundred years of adrenaline: the discovery of autoreceptors
|
|---|---|
| Published in |
Clinical Autonomic Research, June 1999
|
| DOI | 10.1007/bf02281628 |
| Pubmed ID | |
| Authors |
M. R. Bennett |
| Abstract |
The active principle of suprenal extract that produces its pressor effects was isolated by the joint research of John Abel in 1899 and Jokichi Takamine in 1901. Within three years Elliott, working in Langley's laboratory, suggested that this active principle, referred to by British physiologists as "adrenaline" and named "Adrenalin" by Takamine, was released from sympathetic nerve terminals to act on smooth muscle cells. However, it was not until 1946 that von Euler showed that demythelated adrenaline (noradrenaline) rather than adrenaline is a sympathetic transmitter. The possibility that this sympathetic transmitter could also act on nerve terminals was not developed until 1971. Research on autoreceptors culminated in the identification of adrenergic receptors on nerve terminals different to those on muscle cells. This paper assesses the contributions that established the idea of the adrenergic autoreceptor, 100 years after the discovery of adrenaline. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 2% |
| Unknown | 48 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 20% |
| Student > Master | 7 | 14% |
| Student > Ph. D. Student | 7 | 14% |
| Student > Doctoral Student | 4 | 8% |
| Professor | 3 | 6% |
| Other | 9 | 18% |
| Unknown | 9 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 14 | 29% |
| Medicine and Dentistry | 8 | 16% |
| Agricultural and Biological Sciences | 8 | 16% |
| Neuroscience | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 9 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2024.
All research outputs
#3,270,972
of 22,780,165 outputs
Outputs from Clinical Autonomic Research
#110
of 775 outputs
Outputs of similar age
#2,530
of 35,064 outputs
Outputs of similar age from Clinical Autonomic Research
#1
of 2 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 775 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 85% of its peers.
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We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them