| Title |
Ribavirin's antiviral mechanism of action: lethal mutagenesis?
|
|---|---|
| Published in |
Journal of Molecular Medicine, February 2014
|
| DOI | 10.1007/s00109-001-0308-0 |
| Pubmed ID | |
| Authors |
Shane Crotty, Craig Cameron, Raul Andino |
| Abstract |
Ribavirin, an antiviral drug discovered in 1972, is interesting and important for three reasons: (a) it exhibits antiviral activity against a broad range of RNA viruses; (b) it is currently used clinically to treat hepatitis C virus infections, respiratory syncytial virus infections, and Lassa fever virus infections; and (c) ribavirin's mechanism of action has remained unclear for many years. Here we recount the history of ribavirin and review recent reports regarding ribavirin's mechanism of action, including our studies demonstrating that ribavirin is an RNA virus mutagen and ribavirin's primary antiviral mechanism of action against a model RNA virus is via lethal mutagenesis of the RNA virus genomes. Implications for the development of improved versions of ribavirin and for the development of novel antiviral drugs are discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Norway | 1 | <1% |
| Hungary | 1 | <1% |
| Venezuela, Bolivarian Republic of | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 148 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 21% |
| Student > Master | 21 | 14% |
| Researcher | 20 | 13% |
| Student > Bachelor | 19 | 12% |
| Student > Postgraduate | 11 | 7% |
| Other | 22 | 14% |
| Unknown | 29 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 24% |
| Medicine and Dentistry | 22 | 14% |
| Biochemistry, Genetics and Molecular Biology | 20 | 13% |
| Immunology and Microbiology | 15 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Other | 19 | 12% |
| Unknown | 33 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2020.
All research outputs
#3,270,972
of 22,780,165 outputs
Outputs from Journal of Molecular Medicine
#123
of 1,550 outputs
Outputs of similar age
#34,409
of 224,193 outputs
Outputs of similar age from Journal of Molecular Medicine
#1
of 25 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,550 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,193 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.