| Title |
The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia
|
|---|---|
| Published in |
Psychopharmacology, November 2003
|
| DOI | 10.1007/s00213-003-1709-2 |
| Pubmed ID | |
| Authors |
Joseph T. Coyle, Guochuan Tsai |
| Abstract |
Numerous clinical studies demonstrate that subanaesthetic doses of dissociative anaesthetics, which are non-competitive antagonists at the NMDA receptor, replicate in normal subjects the cognitive impairments, negative symptoms and brain functional abnormalities of schizophrenia. Post-mortem and genetic studies have identified several abnormalities associated with schizophrenia that would interfere with the activation of the glycine modulatory site on the NMDA receptor. Placebo controlled clinical trials with agents that directly or indirectly activate the glycine modulatory site consistently reduce negative symptoms and frequently improve cognition in patients with chronic schizophrenia, who are receiving concurrent typical antipsychotics. Thus, there is convincing evidence that the glycine modulatory site on the NMDA receptor is a valid therapeutic target for improving cognition and associated negative symptoms in schizophrenia. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 4% |
| United Kingdom | 3 | 2% |
| Austria | 1 | <1% |
| Denmark | 1 | <1% |
| Chile | 1 | <1% |
| Unknown | 133 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 21% |
| Student > Bachelor | 22 | 15% |
| Researcher | 17 | 12% |
| Student > Doctoral Student | 15 | 10% |
| Professor > Associate Professor | 11 | 8% |
| Other | 32 | 22% |
| Unknown | 18 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 30 | 21% |
| Medicine and Dentistry | 27 | 19% |
| Agricultural and Biological Sciences | 27 | 19% |
| Neuroscience | 17 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Other | 10 | 7% |
| Unknown | 25 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2021.
All research outputs
#5,987,747
of 22,780,165 outputs
Outputs from Psychopharmacology
#1,749
of 5,343 outputs
Outputs of similar age
#25,756
of 132,779 outputs
Outputs of similar age from Psychopharmacology
#9
of 21 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 5,343 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 132,779 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.