| Chapter title |
The Iron Metallome in Eukaryotic Organisms
|
|---|---|
| Chapter number | 8 |
| Book title |
Metallomics and the Cell
|
| Published in |
Metal ions in life sciences, December 2012
|
| DOI | 10.1007/978-94-007-5561-1_8 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-075560-4, 978-9-40-075561-1
|
| Authors |
Adrienne C. Dlouhy, Caryn E. Outten, Dlouhy, Adrienne C., Outten, Caryn E. |
| Editors |
Lucia Banci |
| Abstract |
This chapter is focused on the iron metallome in eukaryotes at the cellular and subcellular level, including properties, utilization in metalloproteins, trafficking, storage, and regulation of these processes. Studies in the model eukaryote Saccharomyces cerevisiae and mammalian cells will be highlighted. The discussion of iron properties will center on the speciation and localization of intracellular iron as well as the cellular and molecular mechanisms for coping with both low iron bioavailability and iron toxicity. The section on iron metalloproteins will emphasize heme, iron-sulfur cluster, and non-heme iron centers, particularly their cellular roles and mechanisms of assembly. The section on iron uptake, trafficking, and storage will compare methods used by yeast and mammalian cells to import iron, how this iron is brought into various organelles, and types of iron storage proteins. Regulation of these processes will be compared between yeast and mammalian cells at the transcriptional, post-transcriptional, and post-translational levels. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 114 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 19% |
| Student > Master | 12 | 11% |
| Researcher | 11 | 10% |
| Student > Bachelor | 10 | 9% |
| Student > Postgraduate | 5 | 4% |
| Other | 13 | 11% |
| Unknown | 41 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 18% |
| Agricultural and Biological Sciences | 19 | 17% |
| Medicine and Dentistry | 8 | 7% |
| Neuroscience | 4 | 4% |
| Chemistry | 4 | 4% |
| Other | 15 | 13% |
| Unknown | 44 | 39% |