| Title |
Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes
|
|---|---|
| Published in |
Chromosome Research, January 2008
|
| DOI | 10.1007/s10577-007-1185-3 |
| Pubmed ID | |
| Authors |
M. C. Wallis, P. D. Waters, M. L. Delbridge, P. J. Kirby, A. J. Pask, F. Grützner, W. Rens, M. A. Ferguson-Smith, J. A. M. Graves |
| Abstract |
In eutherian ('placental') mammals, sex is determined by the presence or absence of the Y chromosome-borne gene SRY, which triggers testis determination. Marsupials also have a Y-borne SRY gene, implying that this mechanism is ancestral to therians, the SRY gene having diverged from its X-borne homologue SOX3 at least 180 million years ago. The rare exceptions have clearly lost and replaced the SRY mechanism recently. Other vertebrate classes have a variety of sex-determining mechanisms, but none shares the therian SRY-driven XX female:XY male system. In monotreme mammals (platypus and echidna), which branched from the therian lineage 210 million years ago, no orthologue of SRY has been found. In this study we show that its partner SOX3 is autosomal in platypus and echidna, mapping among human X chromosome orthologues to platypus chromosome 6, and to the homologous chromosome 16 in echidna. The autosomal localization of SOX3 in monotreme mammals, as well as non-mammal vertebrates, implies that SRY is absent in Prototheria and evolved later in the therian lineage 210-180 million years ago. Sex determination in platypus and echidna must therefore depend on another male-determining gene(s) on the Y chromosomes, or on the different dosage of a gene(s) on the X chromosomes. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| Australia | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Mexico | 1 | 1% |
| United States | 1 | 1% |
| France | 1 | 1% |
| Unknown | 75 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 20% |
| Researcher | 14 | 18% |
| Student > Ph. D. Student | 13 | 16% |
| Professor > Associate Professor | 8 | 10% |
| Student > Doctoral Student | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 17 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 42% |
| Biochemistry, Genetics and Molecular Biology | 16 | 20% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Unspecified | 2 | 3% |
| Environmental Science | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 19 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2023.
All research outputs
#4,511,548
of 22,780,165 outputs
Outputs from Chromosome Research
#64
of 507 outputs
Outputs of similar age
#21,313
of 156,511 outputs
Outputs of similar age from Chromosome Research
#1
of 4 outputs
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