| Title |
The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children
|
|---|---|
| Published in |
European Journal of Nutrition, January 2018
|
| DOI | 10.1007/s00394-017-1601-1 |
| Pubmed ID | |
| Authors |
Sanna Vähämiko, Asta Laiho, Riikka Lund, Erika Isolauri, Seppo Salminen, Kirsi Laitinen |
| Abstract |
Dietary supplementation with probiotics during pregnancy has been suggested to decrease the risk for obesity in women after delivery and to minimize excessive weight gain in their children. Epigenetic DNA methylation has been proposed to impact on gene activity, thereby providing a plausible molecular mechanism for a broad range of biological processes and diseases. This pilot study aimed to evaluate whether probiotic supplementation during pregnancy could modify the DNA methylation status of the promoters of obesity and weight gain-related genes in mothers and their children. A sample of 15 pregnant women was taken from a prospective, randomized mother and infant nutrition and probiotic study. Seven women received the probiotic supplementation and eight served as controls. The women's and their children's DNA methylation status of obesity (623 genes) and weight gain-related (433) gene promoters were analyzed from blood samples at the mean of 9.8 months (range 6.1-12.7 months) postpartum. Probiotic supplementation led to significantly decreased levels of DNA methylation in 37 gene promoters and increased levels of DNA methylation in one gene promoter in women. In their children, 68 gene promoters were significantly affected consistently with a lower level of DNA methylation in the probiotic group. On the basis of our pilot study, we suggest that probiotic supplementation during pregnancy may affect the DNA methylation status of certain promoters of obesity and weight gain-related genes both in mothers and their children, thereby providing a potential mechanism for long-lasting health effects. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| Sweden | 1 | 13% |
| Portugal | 1 | 13% |
| France | 1 | 13% |
| Ireland | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Scientists | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 175 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 27 | 15% |
| Researcher | 20 | 11% |
| Student > Master | 20 | 11% |
| Other | 12 | 7% |
| Student > Ph. D. Student | 9 | 5% |
| Other | 28 | 16% |
| Unknown | 59 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 19% |
| Biochemistry, Genetics and Molecular Biology | 24 | 14% |
| Nursing and Health Professions | 21 | 12% |
| Agricultural and Biological Sciences | 15 | 9% |
| Immunology and Microbiology | 4 | 2% |
| Other | 14 | 8% |
| Unknown | 64 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2021.
All research outputs
#1,675,012
of 23,015,156 outputs
Outputs from European Journal of Nutrition
#430
of 2,406 outputs
Outputs of similar age
#41,362
of 442,518 outputs
Outputs of similar age from European Journal of Nutrition
#10
of 39 outputs
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