| Title |
Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city
|
|---|---|
| Published in |
Human Genetics, April 2004
|
| DOI | 10.1007/s00439-004-1125-7 |
| Pubmed ID | |
| Authors |
Carolina Bonilla, Mark D. Shriver, Esteban J. Parra, Alfredo Jones, José R. Fernández |
| Abstract |
Hispanic and African American populations exhibit an increased risk of obesity compared with populations of European origin, a feature that may be related to inherited risk alleles from Native American and West African parental populations. However, a relationship between West African ancestry and obesity-related traits, such as body mass index (BMI), fat mass (FM), and fat-free mass (FFM), and with bone mineral density (BMD) in African American women has only recently been reported. In order to evaluate further the influence of ancestry on body composition phenotypes, we studied a Hispanic population with substantial European, West African, and Native American admixture. We ascertained a sample of Puerto Rican women living in New York ( n=64), for whom we measured BMI and body composition variables, such as FM, FFM, percent body fat, and BMD. Additionally, skin pigmentation was measured as the melanin index by reflectance spectroscopy. We genotyped 35 autosomal ancestry informative markers and estimated population and individual ancestral proportions in terms of European, West African, and Native American contributions to this population. The ancestry proportions corresponding to the three parental populations are: 53.3+/-2.8% European, 29.1+/-2.3% West African, and 17.6+/-2.4% Native American. We detected significant genetic structure in this population with a number of different tests. A highly significant correlation was found between skin pigmentation and individual ancestry ( R(2)=0.597, P<0.001) that was not attributable to differences in socioeconomic status. A significant association was also found between BMD and European admixture ( R(2)=0.065, P=0.042), but no such correlation was evident with BMI or the remaining body composition measurements. We discuss the implications of our findings for the potential use of this Hispanic population for admixture mapping. |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 7% |
| Uruguay | 3 | 4% |
| Brazil | 3 | 4% |
| United Kingdom | 1 | 1% |
| South Africa | 1 | 1% |
| Canada | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 57 | 79% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 26% |
| Student > Ph. D. Student | 10 | 14% |
| Professor > Associate Professor | 8 | 11% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 6 | 8% |
| Other | 13 | 18% |
| Unknown | 8 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 40% |
| Biochemistry, Genetics and Molecular Biology | 12 | 17% |
| Medicine and Dentistry | 7 | 10% |
| Social Sciences | 6 | 8% |
| Immunology and Microbiology | 3 | 4% |
| Other | 3 | 4% |
| Unknown | 12 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2020.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Human Genetics
#1,014
of 2,957 outputs
Outputs of similar age
#20,899
of 62,057 outputs
Outputs of similar age from Human Genetics
#4
of 11 outputs
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