| Title |
The neurochemistry of phenylketonuria
|
|---|---|
| Published in |
European Journal of Pediatrics, September 2000
|
| DOI | 10.1007/pl00014370 |
| Pubmed ID | |
| Authors |
Robert Surtees, Nenad Blau |
| Abstract |
The mechanisms by which deficiency of hepatic phenylalanine hydroxylase causes central nervous system disease are reviewed. The neurological disease appears to be secondary to increased concentrations of phenylalanine and a decrease in the concentrations of other large neutral amino acids, especially methionine and tyrosine, within the central nervous system. This causes a deficiency of the neurotransmitter dopamine, reduced protein synthesis and demyelination. Similar mechanisms appear to be operating when blood phenylalanine concentrations are in the range expected for early continuously treated phenylketonuria. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | <1% |
| Norway | 1 | <1% |
| Unknown | 137 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 23 | 17% |
| Student > Ph. D. Student | 22 | 16% |
| Student > Bachelor | 20 | 14% |
| Researcher | 10 | 7% |
| Student > Doctoral Student | 8 | 6% |
| Other | 21 | 15% |
| Unknown | 35 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 24% |
| Biochemistry, Genetics and Molecular Biology | 16 | 12% |
| Agricultural and Biological Sciences | 16 | 12% |
| Psychology | 6 | 4% |
| Neuroscience | 4 | 3% |
| Other | 23 | 17% |
| Unknown | 40 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2023.
All research outputs
#4,836,164
of 25,374,647 outputs
Outputs from European Journal of Pediatrics
#1,078
of 4,394 outputs
Outputs of similar age
#5,698
of 37,745 outputs
Outputs of similar age from European Journal of Pediatrics
#2
of 13 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,394 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 37,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.