| Title |
Seizures and epilepsy in herpes simplex virus encephalitis: current concepts and future directions of pathogenesis and management
|
|---|---|
| Published in |
Journal of Neurology, April 2012
|
| DOI | 10.1007/s00415-012-6494-6 |
| Pubmed ID | |
| Authors |
Johann Sellner, Eugen Trinka |
| Abstract |
Mortality related to herpes simplex virus encephalitis (HSE) dropped dramatically with the systematic initiation of antiviral treatment in encephalitic syndromes. Further efforts need to be taken to reduce long-term morbidity in the survivors. In this regard, the high rate of postencephalitic epilepsy, which is frequently refractory to medical treatment, contributes significantly to the unfavorable clinical outcome of the disease. Seizures during the acute phase of HSE are the main risk for the development of postencephalitic epilepsy. Yet, there are no randomized controlled trials for the management of acute seizures, preventive measures or the ideal duration of antiepileptic treatment. Hence, concepts for the medical treatment of seizures during the acute phase of HSE and postencephalitic epilepsy are eagerly awaited. Epilepsy surgery is a potential treatment option for the latter, but only promising in a subgroup of patients suffering from unilateral mesio-temporal lobe epilepsy and congruent neuropsychological impairment. Relapsing HSE and post-infectious autoimmune conditions can lead to seizures in the aftermath of acute HSE. These conditions need to be kept in mind in order to promptly assure the initiation of accurate diagnostic steps and respective treatment. The purpose of this review is to summarize the current pathogenetical understanding, clinical and diagnostic considerations, and treatment options of seizures in acute HSE and postencephalitic epilepsy. |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 102 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 16% |
| Student > Ph. D. Student | 11 | 10% |
| Student > Postgraduate | 11 | 10% |
| Student > Master | 11 | 10% |
| Other | 10 | 10% |
| Other | 22 | 21% |
| Unknown | 23 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 41% |
| Neuroscience | 14 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Agricultural and Biological Sciences | 3 | 3% |
| Other | 13 | 12% |
| Unknown | 24 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2023.
All research outputs
#4,896,388
of 23,544,006 outputs
Outputs from Journal of Neurology
#1,269
of 4,598 outputs
Outputs of similar age
#32,228
of 163,346 outputs
Outputs of similar age from Journal of Neurology
#6
of 38 outputs
Altmetric has tracked 23,544,006 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,598 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.