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Mendeley readers
Attention Score in Context
| Title |
The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic Pathway
|
|---|---|
| Published in |
Current Biology, November 2008
|
| DOI | 10.1016/j.cub.2008.10.044 |
| Pubmed ID | |
| Authors |
Richard Lundmark, Gary J. Doherty, Mark T. Howes, Katia Cortese, Yvonne Vallis, Robert G. Parton, Harvey T. McMahon |
| Abstract |
Clathrin-independent endocytosis is an umbrella term for a variety of endocytic pathways that internalize numerous cargoes independently of the canonical coat protein Clathrin [1, 2]. Electron-microscopy studies have defined the pleiomorphic CLathrin-Independent Carriers (CLICs) and GPI-Enriched Endocytic Compartments (GEECs) as related major players in such uptake [3, 4]. This CLIC/GEEC pathway relies upon cellular signaling and activation through small G proteins, but mechanistic insight into the biogenesis of its tubular and tubulovesicular carriers is lacking. Here we show that the Rho-GAP-domain-containing protein GRAF1 marks, and is indispensable for, a major Clathrin-independent endocytic pathway. This pathway is characterized by its ability to internalize bacterial exotoxins, GPI-linked proteins, and extracellular fluid. We show that GRAF1 localizes to PtdIns(4,5)P2-enriched, tubular, and punctate lipid structures via N-terminal BAR and PH domains. These membrane carriers are relatively devoid of caveolin1 and flotillin1 but are associated with activity of the small G protein Cdc42. This study provides the first specific noncargo marker for CLIC/GEEC endocytic membranes and demonstrates how GRAF1 can coordinate small G protein signaling and membrane remodeling to facilitate internalization of CLIC/GEEC pathway cargoes. |
Mendeley readers
The data shown below were compiled from readership statistics for 244 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 2% |
| Germany | 2 | <1% |
| France | 1 | <1% |
| Sweden | 1 | <1% |
| Singapore | 1 | <1% |
| China | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 231 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 85 | 35% |
| Researcher | 38 | 16% |
| Student > Master | 23 | 9% |
| Student > Bachelor | 17 | 7% |
| Professor > Associate Professor | 12 | 5% |
| Other | 38 | 16% |
| Unknown | 31 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 99 | 41% |
| Biochemistry, Genetics and Molecular Biology | 59 | 24% |
| Medicine and Dentistry | 11 | 5% |
| Immunology and Microbiology | 7 | 3% |
| Neuroscience | 6 | 2% |
| Other | 28 | 11% |
| Unknown | 34 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2020.
All research outputs
#8,759,452
of 25,837,817 outputs
Outputs from Current Biology
#9,931
of 14,826 outputs
Outputs of similar age
#38,508
of 108,641 outputs
Outputs of similar age from Current Biology
#51
of 86 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,826 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 62.2. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,641 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.