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Microglia: Key players in neurodevelopment and neuronal plasticity

Overview of attention for article published in International Journal of Biochemistry & Cell Biology, December 2017
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242 Mendeley
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Title
Microglia: Key players in neurodevelopment and neuronal plasticity
Published in
International Journal of Biochemistry & Cell Biology, December 2017
DOI 10.1016/j.biocel.2017.11.012
Pubmed ID
Authors

Luba Sominsky, Simone De Luca, Sarah J. Spencer

Abstract

Microglia are the primary innate immune cells in the CNS. Since their initial discovery and characterization, decades of research have revealed their unique roles not only in maintaining immune homeostasis, but also being indispensable to brain development and cognitive function. As such, microglia drive synaptogenesis, synaptic pruning, neurogenesis and neuronal activity. Microglia-specific mutations are implicated in several neurodevelopmental disorders, and dysregulation of microglial function is strongly linked to several pathologies, including cognitive decline and Alzheimer's disease. Importantly, developmental insults can lead to long-term changes in microglial function that may compromise the ability of the adult brain to fight infections and process cognitive information. Adult lifestyle or injury can also lastingly influence microglial morphology and function. Here we highlight key research on microglia's role in neuronal plasticity across the lifespan.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 242 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 242 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 43 18%
Student > Ph. D. Student 38 16%
Student > Master 29 12%
Student > Doctoral Student 22 9%
Researcher 18 7%
Other 37 15%
Unknown 55 23%
Readers by discipline Count As %
Neuroscience 72 30%
Biochemistry, Genetics and Molecular Biology 29 12%
Medicine and Dentistry 23 10%
Agricultural and Biological Sciences 15 6%
Psychology 7 3%
Other 25 10%
Unknown 71 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2018.
All research outputs
#16,725,651
of 25,382,440 outputs
Outputs from International Journal of Biochemistry & Cell Biology
#2,034
of 2,858 outputs
Outputs of similar age
#265,935
of 444,941 outputs
Outputs of similar age from International Journal of Biochemistry & Cell Biology
#17
of 32 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,858 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 444,941 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.