| Title |
The end adjusts the means: Heterochromatin remodelling during terminal cell differentiation
|
|---|---|
| Published in |
Chromosome Research, March 2006
|
| DOI | 10.1007/s10577-005-1021-6 |
| Pubmed ID | |
| Authors |
Sergei A. Grigoryev, Yaroslava A. Bulynko, Evgenya Y. Popova |
| Abstract |
All cells that constitute mature tissues in an eukaryotic organism undergo a multistep process of cell differentiation. At the terminal stage of this process, cells either cease to proliferate forever or rest for a very long period of time. During terminal differentiation, most of the genes that are required for cell 'housekeeping' functions, such as proto-oncogenes and other cell-cycle and cell proliferation genes, become stably repressed. At the same time, nuclear chromatin undergoes dramatic morphological and structural changes at the higher-order levels of chromatin organization. These changes involve both constitutively inactive chromosomal regions (constitutive heterochromatin) and the formerly active genes that become silenced and structurally modified to form facultative heterochromatin. Here we approach terminal cell differentiation as a unique system that allows us to combine biochemical, ultrastructural and molecular genetic techniques to study the relationship between the hierarchy of chromatin higher-order structures in the nucleus and its function(s) in dynamic packing of genetic material in a form that remains amenable to regulation of gene activity and other DNA-dependent cellular processes. |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Russia | 1 | 1% |
| Unknown | 81 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 27% |
| Student > Ph. D. Student | 21 | 25% |
| Student > Bachelor | 8 | 10% |
| Professor > Associate Professor | 6 | 7% |
| Student > Master | 6 | 7% |
| Other | 16 | 19% |
| Unknown | 4 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 42% |
| Biochemistry, Genetics and Molecular Biology | 31 | 37% |
| Physics and Astronomy | 3 | 4% |
| Chemical Engineering | 2 | 2% |
| Medicine and Dentistry | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 4 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#4,694,486
of 22,780,165 outputs
Outputs from Chromosome Research
#69
of 507 outputs
Outputs of similar age
#12,689
of 71,284 outputs
Outputs of similar age from Chromosome Research
#1
of 6 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 507 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them