| Title |
Mechanisms of Pefloxacin-Induced Pain
|
|---|---|
| Published in |
Bulletin of Experimental Biology and Medicine, April 2004
|
| DOI | 10.1023/b:bebm.0000035122.45148.93 |
| Pubmed ID | |
| Authors |
M. L. Kukushkin, S. I. Igonkina, T. A. Guskova |
| Abstract |
In electrophysiological and behavioral experiments on rats we studied the effects of pefloxacin, a member of fluoroquinolone family, on the nociceptive system. Intraperitoneal injection of pefloxacin (80 mg/kg) decreased the thresholds of nociceptive response to noxious stimulation in the hot-plate test. In addition, it decreased the threshold of the late component of nociceptive flexor reflex. Intrathecal application of pefloxacin in a dose of 20 microg provoked allodynia, while the higher dose of 400 microg induced behavioral pattern characteristic of central pain syndrome. It was hypothesized that pain induced by pefloxacin results from disturbances in GABAergic inhibition in the central subdivisions of the nociceptive system. |
Mendeley readers
The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 1 | 100% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2021.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Bulletin of Experimental Biology and Medicine
#194
of 1,416 outputs
Outputs of similar age
#21,863
of 64,942 outputs
Outputs of similar age from Bulletin of Experimental Biology and Medicine
#5
of 9 outputs
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