| Title |
The Clinical Applications of Fluorouracil in Ophthalmic Practice
|
|---|---|
| Published in |
Drugs, September 2012
|
| DOI | 10.2165/00003495-200767020-00005 |
| Pubmed ID | |
| Authors |
Lekha M. Abraham, Dinesh Selva, Robert Casson, Igal Leibovitch |
| Abstract |
Fluorouracil (5-fluorouracil, 5-FU) is a pyrimidine analogue that was originally known for its widespread use as an anticancer drug. The ability of 5-FU to reduce fibroblastic proliferation and subsequent scarring has made it an important adjunct in ocular and periorbital surgeries. It is used in primary glaucoma filtering surgeries and in reviving failing filtering blebs, in dacryocystorhinostomy, pterygium surgery, and in vitreoretinal surgery to prevent proliferative vitreoretinopathy. In addition, 5-FU is also gaining recognition in the treatment and surgical management of ocular surface malignancies like ocular surface squamous neoplasia; however, the specific action of the drug on highly proliferating cells limits its use in primary acquired melanosis of the conjunctiva. When applied topically, this drug has a low rate of sight-threatening adverse effects, is inexpensive, and is easy to administer, making it an important tool in enhancing the success rate in ophthalmic surgery and in reducing the recurrence of ocular surface neoplasia. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Australia | 1 | 2% |
| Unknown | 44 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 8 | 17% |
| Student > Ph. D. Student | 7 | 15% |
| Researcher | 4 | 9% |
| Student > Doctoral Student | 4 | 9% |
| Student > Master | 3 | 7% |
| Other | 8 | 17% |
| Unknown | 12 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 30% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Computer Science | 2 | 4% |
| Chemistry | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 19 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Drugs
#1,511
of 3,464 outputs
Outputs of similar age
#64,171
of 187,311 outputs
Outputs of similar age from Drugs
#539
of 1,379 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,464 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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