| Title |
T cell recognition of weak ligands: roles of signaling, receptor number, and affinity
|
|---|---|
| Published in |
Immunologic Research, March 2011
|
| DOI | 10.1007/s12026-011-8204-3 |
| Pubmed ID | |
| Authors |
Lindsay J. Edwards, Brian D. Evavold |
| Abstract |
T cell recognition of antigen is a crucial aspect of the adaptive immune response. One of the most common means of pathogen immune evasion is mutation of T cell epitopes. T cell recognition of such ligands can result in a variety of outcomes including activation, apoptosis and anergy. The ability of a given T cell to respond to a specific peptide-MHC ligand is regulated by a number of factors, including the affinity, on- and off-rates and half-life of the TCR-peptide-MHC interaction. Interaction of T cells with low-potency ligands results in unique signaling patterns and requires engagement with a larger number of T cell receptors than agonist ligands. This review will address these aspects of T cell interaction with weak ligands and the ways in which these ligands have been utilized therapeutically. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Netherlands | 1 | 1% |
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 72 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 45% |
| Researcher | 9 | 12% |
| Student > Bachelor | 7 | 9% |
| Student > Master | 5 | 7% |
| Professor | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 8 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 37% |
| Biochemistry, Genetics and Molecular Biology | 13 | 17% |
| Immunology and Microbiology | 10 | 13% |
| Medicine and Dentistry | 7 | 9% |
| Chemistry | 4 | 5% |
| Other | 6 | 8% |
| Unknown | 8 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2021.
All research outputs
#4,694,486
of 22,780,165 outputs
Outputs from Immunologic Research
#143
of 904 outputs
Outputs of similar age
#23,066
of 108,657 outputs
Outputs of similar age from Immunologic Research
#1
of 2 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 904 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them