| Title |
Is Phosphodiesterase inhibition a new mechanism of antidepressant action?
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, November 1988
|
| DOI | 10.1007/bf00381071 |
| Pubmed ID | |
| Authors |
D. Bobon, M. Breulet, M. -A. Gerard-Vandenhove, F. Guiot-Goffioul, G. Plomteux, M. Sastre-y-Hernández, M. Schratzer, B. Troisfontaines, R. von Frenckell, H. Wachtel |
| Abstract |
Unlike conventional antidepressants, rolipram (a new approach in the treatment of depression) stimulates both the presynaptic and the postsynaptic component of monoaminergic transmission. Several double blind trials are under way to assess the clinical efficacy and safety of this compound. The present study was a randomized, 4-week interindividual double blind double-dummy comparison with desipramine in inpatients with major (DSM-III) and/or endogenous (ICD-9) depressions. After a minimum washout period of three days the patients received either 0.50 mg rolipram or 25 mg desipramine orally t.i.d. for the first three days, then 0.75 mg rolipram or 50 mg desipramine t.i.d. until day 28. Rating tests were based principally on the AMDP-system and the HAMD scale. The study showed no differences between the two drugs as regards the efficacy, but a definite trend in favour of rolipram as regards the side effects and, in particular, anticholinergic effects. |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 27% |
| Student > Master | 3 | 14% |
| Other | 2 | 9% |
| Student > Bachelor | 2 | 9% |
| Lecturer > Senior Lecturer | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 6 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 23% |
| Neuroscience | 2 | 9% |
| Agricultural and Biological Sciences | 1 | 5% |
| Sports and Recreations | 1 | 5% |
| Nursing and Health Professions | 1 | 5% |
| Other | 4 | 18% |
| Unknown | 8 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2021.
All research outputs
#8,535,472
of 25,374,647 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#535
of 1,636 outputs
Outputs of similar age
#3,771
of 12,985 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#1
of 1 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,636 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
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