| Title |
Structure and function of the Nppa–Nppb cluster locus during heart development and disease
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 2018
|
| DOI | 10.1007/s00018-017-2737-0 |
| Pubmed ID | |
| Authors |
Joyce Man, Phil Barnett, Vincent M. Christoffels |
| Abstract |
Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced in the ventricles after birth. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa-Nppb cluster in vivo has proven to be quite complex and is not well understood. In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster with the cardiomyocyte-intrinsic program of heart regeneration. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 113 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 16% |
| Student > Bachelor | 17 | 15% |
| Researcher | 15 | 13% |
| Student > Master | 9 | 8% |
| Professor | 3 | 3% |
| Other | 7 | 6% |
| Unknown | 44 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 35 | 31% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 9% |
| Medicine and Dentistry | 8 | 7% |
| Agricultural and Biological Sciences | 7 | 6% |
| Materials Science | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 45 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2018.
All research outputs
#15,492,086
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#2,969
of 4,151 outputs
Outputs of similar age
#260,969
of 446,437 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#28
of 51 outputs
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