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Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

Overview of attention for article published in Journal of Clinical Investigation, August 1986
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

patent
2 patents
wikipedia
7 Wikipedia pages

Citations

dimensions_citation
390 Dimensions

Readers on

mendeley
47 Mendeley
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Title
Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.
Published in
Journal of Clinical Investigation, August 1986
DOI 10.1172/jci112584
Pubmed ID
Authors

G C Nicholson, J M Moseley, P M Sexton, F A Mendelsohn, T J Martin

Abstract

Calcitonin receptors have been characterized for the first time in isolated osteoclasts. These receptors have been demonstrated by autoradiographic and biochemical methods, and the cells have also been shown to respond to calcitonin with a dose-dependent increase in cyclic AMP. The receptors in rat osteoclasts are specific and of high affinity (dissociation constant, Kd, 1 to 6 X 10(-10) M), and are present in greater numbers than in any cell previously studied (greater than 10(6) per cell). Chemical cross-linking of 125I-labeled salmon calcitonin to osteoclasts using disuccinimidyl suberate resulted in identification of a receptor component with a relative molecular weight of 80,000-90,000. By counting grains in autoradiographic experiments, we found that greater than 80% of specifically bound radioactivity was associated with multinucleate osteoclasts and the remainder was associated with mononuclear cells that are not osteoblasts, but that may be osteoclast precursors.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 23%
Student > Bachelor 6 13%
Researcher 5 11%
Lecturer > Senior Lecturer 3 6%
Student > Master 3 6%
Other 11 23%
Unknown 8 17%
Readers by discipline Count As %
Medicine and Dentistry 13 28%
Agricultural and Biological Sciences 11 23%
Biochemistry, Genetics and Molecular Biology 7 15%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Chemistry 2 4%
Other 3 6%
Unknown 8 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2018.
All research outputs
#3,799,086
of 25,374,917 outputs
Outputs from Journal of Clinical Investigation
#4,735
of 17,180 outputs
Outputs of similar age
#630
of 10,377 outputs
Outputs of similar age from Journal of Clinical Investigation
#2
of 38 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,180 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 10,377 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.