Title |
Extended-Spectrum β-Lactamases in Klebsiella pneumoniae Bloodstream Isolates from Seven Countries: Dominance and Widespread Prevalence of SHV- and CTX-M-Type β-Lactamases
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Published in |
Antimicrobial Agents and Chemotherapy, October 2003
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DOI | 10.1128/aac.47.11.3554-3560.2003 |
Pubmed ID | |
Authors |
David L. Paterson, Kristine M. Hujer, Andrea M. Hujer, Bethany Yeiser, Michael D. Bonomo, Louis B. Rice, Robert A. Bonomo |
Abstract |
A huge variety of extended-spectrum beta-lactamases (ESBLs) have been detected during the last 20 years. The majority of these have been of the TEM or SHV lineage. We have assessed ESBLs occurring among a collection of 455 bloodstream isolates of Klebsiella pneumoniae, collected from 12 hospitals in seven countries. Multiple beta-lactamases were produced by isolates with phenotypic evidence of ESBL production (mean of 2.7 beta-lactamases per isolate; range, 1 to 5). SHV-type ESBLs were the most common ESBL, occurring in 67.1% (49 of 73) of isolates with phenotypic evidence of ESBL production. In contrast, TEM-type ESBLs (TEM-10 type, -12 type, -26 type, and -63 type) were found in just 16.4% (12 of 73) of isolates. The finding of TEM-10 type and TEM-12 type represents the first detection of a TEM-type ESBL in South America. PER (for Pseudomonas extended resistance)-type beta-lactamases were detected in five of the nine isolates from Turkey and were found with SHV-2-type and SHV-5-type ESBLs in two of the isolates. CTX-M-type ESBLs (bla(CTX-M-2) type and bla(CTX-M-3) type) were found in 23.3% (17 of 73) of isolates and were found in all study countries except for the United States. We also detected CTX-M-type ESBLs in four countries where they have previously not been described-Australia, Belgium, Turkey, and South Africa. The widespread emergence and proliferation of CTX-M-type ESBLs is particularly noteworthy and may have important implications for clinical microbiology laboratories and for physicians treating patients with serious K. pneumoniae infections. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Kenya | 1 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
Guatemala | 1 | <1% |
Mexico | 1 | <1% |
Nigeria | 1 | <1% |
United States | 1 | <1% |
Unknown | 228 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 40 | 17% |
Student > Bachelor | 30 | 13% |
Researcher | 26 | 11% |
Student > Ph. D. Student | 26 | 11% |
Student > Doctoral Student | 16 | 7% |
Other | 41 | 17% |
Unknown | 56 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 41 | 17% |
Biochemistry, Genetics and Molecular Biology | 34 | 14% |
Medicine and Dentistry | 32 | 14% |
Immunology and Microbiology | 28 | 12% |
Veterinary Science and Veterinary Medicine | 13 | 6% |
Other | 23 | 10% |
Unknown | 64 | 27% |