| Title |
Hyperglycaemia is associated with cancer-related but not non-cancer-related deaths: evidence from the IPC cohort
|
|---|---|
| Published in |
Diabetologia, January 2018
|
| DOI | 10.1007/s00125-017-4540-8 |
| Pubmed ID | |
| Authors |
Jean-Marc Simon, Frederique Thomas, Sebastien Czernichow, Olivier Hanon, Cedric Lemogne, Tabassome Simon, Bruno Pannier, Nicolas Danchin |
| Abstract |
Hyperglycaemia has been associated with the incidence of all and specific types of cancer, distinct from the risks related to diabetes. The relationships between blood glucose and mortality rates related to all and specific cancers were analysed in comparison with all-cause or non-cancer-related mortality rates in a large, general primary care population in France. Between January 1991 and December 2008, 301,948 participants (193,221 men and 108,727 women), aged 16-95 years (mean ± SD 44.8 ± 12.0 years for men and 45.1 ± 14.2 years for women), had a health check at the IPC Centre. All data collected in standard conditions during the health checks-up were used for statistical analysis All examinations were performed under fasting conditions and included a blood glucose measurement. Participants with known diabetes (<9%) were excluded from the analysis. Participants were classified into quintiles based on their blood glucose measurement and were followed for a maximum of 17 years (mean ± SD 9.2 ± 4.7 years) to assess all-cause, cancer and non-cancer mortality rates. A non-linear relationship was observed between cancer mortality rates and blood glucose quintile after adjustment for age and sex. There was a significant association between the group with the highest blood glucose level and cancer-related death (multivariate Cox model, HR [95% CI] 1.17 [1.03, 1.34]), while the group with normoglycaemia showed no association with cancer-related deaths. We did not observe a relationship between blood glucose and all-cause or non-cancer mortality rates. An excess risk of death was observed in the highest blood glucose quintile for gastrointestinal cancer and leukaemia. Adjustments for diabetes and aspirin use did not modify the results. However, this excess risk disappeared with use of glucose-lowering agents (HR [95% CI] 1.03 [0.74, 1.43]). Hyperglycaemia is associated with significantly higher rates of cancer-related deaths, particularly in gastrointestinal cancer and leukaemia, but not with non-cancer-related deaths. The association is retained when taking into account confounding factors, including chronic aspirin treatment. |
X Demographics
The data shown below were collected from the profiles of 36 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 14% |
| United Kingdom | 4 | 11% |
| Spain | 2 | 6% |
| Netherlands | 2 | 6% |
| Mexico | 1 | 3% |
| Canada | 1 | 3% |
| France | 1 | 3% |
| Japan | 1 | 3% |
| Paraguay | 1 | 3% |
| Other | 6 | 17% |
| Unknown | 12 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 64% |
| Scientists | 7 | 19% |
| Practitioners (doctors, other healthcare professionals) | 6 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 14% |
| Librarian | 2 | 7% |
| Student > Doctoral Student | 2 | 7% |
| Other | 2 | 7% |
| Researcher | 2 | 7% |
| Other | 4 | 14% |
| Unknown | 12 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 21% |
| Nursing and Health Professions | 4 | 14% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Engineering | 1 | 4% |
| Unknown | 15 | 54% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2018.
All research outputs
#1,880,339
of 25,058,309 outputs
Outputs from Diabetologia
#1,026
of 5,334 outputs
Outputs of similar age
#42,347
of 454,013 outputs
Outputs of similar age from Diabetologia
#27
of 62 outputs
Altmetric has tracked 25,058,309 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,334 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.5. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 454,013 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.