| Title |
Flupirtine, a re-discovered drug, revisited
|
|---|---|
| Published in |
Inflammation Research, January 2013
|
| DOI | 10.1007/s00011-013-0592-5 |
| Pubmed ID | |
| Authors |
Istvan Szelenyi |
| Abstract |
Flupirtine was developed long before K(V)7 (KCNQ) channels were known. However, it was clear from the beginning that flupirtine is neither an opioid nor a nonsteroidal anti-inflammatory analgesic. Its unique muscle relaxing activity was discovered by serendipity. In the meantime, broad and intensive research has resulted in a partial clarification of its mode of action. Flupirtine is the first therapeutically used K(V)7 channel activator with additional GABA(A)ergic mechanisms and thus the first representative of a novel class of analgesics. The presently accepted main mode of its action, potassium K(V)7 (KCNQ) channel activation, opens a series of further therapeutic possibilities. One of them has now been realized: its back-up compound, the bioisostere retigabine, has been approved for the treatment of epilepsy. |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 25% |
| Other | 7 | 13% |
| Professor | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Student > Doctoral Student | 3 | 6% |
| Other | 9 | 17% |
| Unknown | 14 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 21% |
| Agricultural and Biological Sciences | 9 | 17% |
| Chemistry | 5 | 9% |
| Neuroscience | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Other | 6 | 11% |
| Unknown | 14 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2023.
All research outputs
#7,451,284
of 22,780,967 outputs
Outputs from Inflammation Research
#241
of 954 outputs
Outputs of similar age
#86,084
of 285,268 outputs
Outputs of similar age from Inflammation Research
#2
of 6 outputs
Altmetric has tracked 22,780,967 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 954 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,268 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.