| Title |
Thiamine deficiency and wernicke's encephalopathy in AIDS
|
|---|---|
| Published in |
Metabolic Brain Disease, December 1991
|
| DOI | 10.1007/bf00996920 |
| Pubmed ID | |
| Authors |
Roger F. Butterworth, Christiane Gaudreau, Jean Vincelette, Anne-Marie Bourgault, Francois Lamothe, Anne-Marie Nutini |
| Abstract |
Several neuropathological reports in the last 5 years have described brain lesions characteristic of Wernicke's Encephalopathy in patients with AIDS. Using the erythrocyte transketolase activation assay, we now report biochemical evidence of thiamine deficiency in 9/39 (23%) of patients with AIDS or AIDS-related complex. In no cases was there history of alcohol abuse nor were there clinical signs of Wernicke's Encephalopathy. Thiamine deficiency in these patients most likely results from the cachexia and catabolic state characteristic of AIDS. In view of (i) the confirmed neuropathological evidence of Wernicke's Encephalopathy in AIDS patients, (ii) the significant thiamine deficiency in these patients and (iii) the difficulties of clinical diagnosis of Wernicke's Encephalopathy, it is recommended that dietary thiamine supplementation be initiated in all newly diagnosed cases of AIDS or AIDS-related complex. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Taiwan | 1 | 4% |
| Unknown | 22 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 22% |
| Student > Bachelor | 4 | 17% |
| Student > Postgraduate | 3 | 13% |
| Other | 2 | 9% |
| Student > Ph. D. Student | 2 | 9% |
| Other | 4 | 17% |
| Unknown | 3 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 22% |
| Medicine and Dentistry | 5 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 13% |
| Biochemistry, Genetics and Molecular Biology | 3 | 13% |
| Immunology and Microbiology | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 4 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2023.
All research outputs
#7,451,584
of 22,780,967 outputs
Outputs from Metabolic Brain Disease
#333
of 1,050 outputs
Outputs of similar age
#12,465
of 61,711 outputs
Outputs of similar age from Metabolic Brain Disease
#1
of 1 outputs
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