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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Glucocorticoids suppress brown adipose tissue function in humans: A double‐blind placebo‐controlled study
|
|---|---|
| Published in |
Diabetes, Obesity & Metabolism, December 2017
|
| DOI | 10.1111/dom.13157 |
| Pubmed ID | |
| Authors |
Moe Thuzar, Weikiat Phillip Law, Jeyakantha Ratnasingam, Christina Jang, Goce Dimeski, Ken K. Y. Ho |
| Abstract |
To investigate the effect of glucocorticoids on BAT function in humans MATERIALS & METHODS: In a randomised double-blind cross-over design, 13 healthy adults underwent 1 week of oral prednisolone (15mg/day) and placebo treatment with an intervening 2-week wash-out period. BAT function was assessed in response to cooling (19(0) C) and to a standardised meal, by measuring fluoro-deoxyglucose (FDG) uptake using Positron Emission Tomography-Computed Tomography and skin temperatures overlying the supraclavicular (SCL) BAT depots using infrared thermography. Postprandial energy and substrate metabolism was assessed by indirect calorimetry. During cooling, prednisolone significantly reduced BAT FDG uptake (standardised uptake value, SUVmax, 6.1±2.2 vs 3.7±1.2; P<0.05) and SCL temperature (-0.45±0.1 vs -1.0±0.1(0) C; P<0.01) compared to placebo. Postprandially, prednisolone significantly blunted the rise in SCL temperature (+0.2±0.1 vs -0.3±0.1(0) C; P<0.05), enhanced energy production (+221±17 vs +283±27 kcal/day; P<0.01) and lipid synthesis (+16.3±3.2 vs +23.6±4.9 mg/min; P<0.05). The prednisolone-induced reduction in SCL temperature significantly correlated with the reduction in FDG uptake (r=0.65, P<0.05), while the increase in energy production significantly correlated with the increase in lipogenesis (r=0.6, P<0.05). Prolonged glucocorticoid suppresses the function of human BAT. The enhancement of energy production and lipogenesis in the face of reduced dissipation of energy as heat suggests that glucocorticoids channel energy towards fat storage after nutrient intake. This is a novel mechanism of glucocorticoid-induced obesity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 73 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 22% |
| Student > Bachelor | 9 | 12% |
| Student > Ph. D. Student | 8 | 11% |
| Professor > Associate Professor | 5 | 7% |
| Student > Doctoral Student | 3 | 4% |
| Other | 14 | 19% |
| Unknown | 18 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 22% |
| Biochemistry, Genetics and Molecular Biology | 12 | 16% |
| Nursing and Health Professions | 4 | 5% |
| Sports and Recreations | 4 | 5% |
| Agricultural and Biological Sciences | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 24 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2023.
All research outputs
#3,711,488
of 25,382,440 outputs
Outputs from Diabetes, Obesity & Metabolism
#954
of 3,581 outputs
Outputs of similar age
#76,725
of 445,980 outputs
Outputs of similar age from Diabetes, Obesity & Metabolism
#28
of 48 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,581 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,980 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.