| Title |
Analysis of peptaibol sequence composition: implications for in vivo synthesis and channel formation
|
|---|---|
| Published in |
European Biophysics Journal, October 2003
|
| DOI | 10.1007/s00249-003-0348-1 |
| Pubmed ID | |
| Authors |
L. Whitmore, B. A. Wallace |
| Abstract |
The sequence entries in the Peptaibol Database were analysed to provide information on compositional features of this unusual family of peptides. The non-standard amino acid alpha-aminoisobutyric acid represents almost 40% of the residues in all the known sequences. Glutamine is the only significant polar residue in peptaibols, and the position and number of these residues appear to be related to their functional properties as ion channels. Aromatic residues are clustered at the termini, which may contribute to stabilization of the peptide vertically within the bilayer. The peptide chain length is strongly weighted towards the longer members of the family (16-20 residues) and likely to be an important feature in their mode of action as transmembrane permeabilizers. The significant skewing towards even numbers of residues and the bias in pairwise distributions of amino acids have implications for the nature of the in vivo synthesis of these peptides via large non-ribosomal protein complexes. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 18% |
| Researcher | 3 | 18% |
| Professor | 2 | 12% |
| Student > Ph. D. Student | 2 | 12% |
| Professor > Associate Professor | 2 | 12% |
| Other | 2 | 12% |
| Unknown | 3 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 7 | 41% |
| Agricultural and Biological Sciences | 4 | 24% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Computer Science | 1 | 6% |
| Arts and Humanities | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 3 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2023.
All research outputs
#7,756,853
of 23,578,918 outputs
Outputs from European Biophysics Journal
#104
of 498 outputs
Outputs of similar age
#18,149
of 52,710 outputs
Outputs of similar age from European Biophysics Journal
#2
of 7 outputs
Altmetric has tracked 23,578,918 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 498 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
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