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X Demographics
Mendeley readers
Attention Score in Context
| Title |
In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
|
|---|---|
| Published in |
Scientific Reports, January 2018
|
| DOI | 10.1038/s41598-017-18644-9 |
| Pubmed ID | |
| Authors |
Imran Khan, Ashutosh Bahuguna, Pradeep Kumar, Vivek K. Bajpai, Sun Chul Kang |
| Abstract |
Carvacrol is present abundantly in the essential oils of many medicinal plants and well known for its numerous biological activities. Since partial solubility in water and physicochemical instability limits its industrial uses, the present study was performed to prepare a carvacrol nanoemulsion (CANE) using an ultrasonication technique and further evaluation of its anticancer potential against human lung adenocarcinoma A549 cells. The nanoemulsion formulation was optimized by varying carvacrol and polysorbate 80 ratios and characterized by dynamic light scattering (DLS), which revealed a negative surface charge with a mean droplet size between 105.5 ± 3.4 to 169.8 ± 4.9 nm. The CANE induced reactive oxygen species (ROS) production in A549 cells, leading to activation of key regulators of apoptosis such as p-JNK, Bax and Bcl2 as well as release of cytochrome C, and activation of the caspase cascade. Suppression of mitochondrial ROS using Mito-TEMPO reversed the apoptotic potential of CANE signifying involvement of mitochondrial ROS in cell death. Beside, CANE displayed a strong antitumor potential in vivo using an athymic nude mice model. The results strongly support that CANE induced apoptosis in A549 cells by induction of ROS and could be a promising candidate for lung cancer therapy. |
X Demographics
The data shown below were collected from the profiles of 41 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 14 | 34% |
| United States | 2 | 5% |
| El Salvador | 1 | 2% |
| Argentina | 1 | 2% |
| India | 1 | 2% |
| Unknown | 22 | 54% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 98% |
| Scientists | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 133 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 19% |
| Student > Master | 17 | 13% |
| Student > Bachelor | 17 | 13% |
| Researcher | 9 | 7% |
| Other | 5 | 4% |
| Other | 20 | 15% |
| Unknown | 40 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 11% |
| Agricultural and Biological Sciences | 14 | 11% |
| Chemistry | 8 | 6% |
| Medicine and Dentistry | 7 | 5% |
| Other | 19 | 14% |
| Unknown | 45 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2023.
All research outputs
#982,794
of 24,356,663 outputs
Outputs from Scientific Reports
#10,117
of 132,498 outputs
Outputs of similar age
#23,702
of 451,808 outputs
Outputs of similar age from Scientific Reports
#328
of 4,086 outputs
Altmetric has tracked 24,356,663 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 132,498 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,808 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 4,086 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.