| Title |
The LRRK2 signalling system
|
|---|---|
| Published in |
Cell and Tissue Research, January 2018
|
| DOI | 10.1007/s00441-017-2759-9 |
| Pubmed ID | |
| Authors |
Alice Price, Claudia Manzoni, Mark R. Cookson, Patrick A. Lewis |
| Abstract |
The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the cell. Because of the complexities of the signal transduction pathways in which LRRK2 is involved, it has been challenging to generate a clear idea as to how mutations and disease associated variants in this gene are altered in disease. Understanding the events in which LRRK2 is involved at a systems level is therefore critical to fully understand the biology and pathobiology of this protein and is the subject of this review. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 18% |
| Student > Ph. D. Student | 19 | 17% |
| Student > Bachelor | 16 | 15% |
| Student > Master | 13 | 12% |
| Student > Doctoral Student | 6 | 5% |
| Other | 13 | 12% |
| Unknown | 23 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 27% |
| Neuroscience | 20 | 18% |
| Medicine and Dentistry | 11 | 10% |
| Agricultural and Biological Sciences | 7 | 6% |
| Chemistry | 3 | 3% |
| Other | 8 | 7% |
| Unknown | 31 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2018.
All research outputs
#16,061,913
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#1,468
of 2,279 outputs
Outputs of similar age
#275,314
of 446,512 outputs
Outputs of similar age from Cell and Tissue Research
#31
of 51 outputs
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So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
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We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.