Title |
Caffeine analogs: biomedical impact
|
---|---|
Published in |
Cellular and Molecular Life Sciences, May 2007
|
DOI | 10.1007/s00018-007-7051-9 |
Pubmed ID | |
Authors |
J. W. Daly |
Abstract |
Caffeine, widely consumed in beverages, and many xanthine analogs have had a major impact on biomedical research. Caffeine and various analogs, the latter designed to enhance potency and selectivity toward specific biological targets, have played key roles in defining the nature and role of adenosine receptors, phosphodiesterases, and calcium release channels in physiological processes. Such xanthines and other caffeine-inspired heterocycles now provide important research tools and potential therapeutic agents for intervention in Alzheimer's disease, asthma, cancer, diabetes, and Parkinson's disease. Such compounds also have activity as analgesics, antiinflammatories, antitussives, behavioral stimulants, diuretics/natriuretics, and lipolytics. Adverse effects can include anxiety, hypertension, certain drug interactions, and withdrawal symptoms. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Austria | 1 | <1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Japan | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 235 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 42 | 17% |
Student > Master | 41 | 17% |
Student > Ph. D. Student | 36 | 15% |
Researcher | 19 | 8% |
Student > Doctoral Student | 14 | 6% |
Other | 27 | 11% |
Unknown | 63 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 16% |
Medicine and Dentistry | 29 | 12% |
Biochemistry, Genetics and Molecular Biology | 26 | 11% |
Chemistry | 15 | 6% |
Sports and Recreations | 13 | 5% |
Other | 52 | 21% |
Unknown | 68 | 28% |