| Title |
Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Antioxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy
|
|---|---|
| Published in |
Current Pharmacology Reports, January 2015
|
| DOI | 10.1007/s40495-015-0017-y |
| Pubmed ID | |
| Authors |
Francisco Fuentes, Ximena Paredes-Gonzalez, Ah-Ng Tony Kong |
| Abstract |
Glucosinolates are a group of sulfur-containing glycosides found in many plant species, including cruciferous vegetables such as broccoli, cabbage, brussels sprouts, and cauliflower. Accumulating evidence increasingly supports the beneficial effects of dietary glucosinolates on overall health, including as potential anti-cancer agents, because of their role in the prevention of the initiation of carcinogenesis via the induction of cellular defense detoxifying/antioxidant enzymes and their epigenetic mechanisms, including modification of the CpG methylation of cancer-related genes, histone modification regulation and changes in the expression of miRNAs. In this context, the defense mechanism mediated by Nrf2-antioxidative stress and anti-inflammatory signaling pathways can contribute to cellular protection against oxidative stress and reactive metabolites of carcinogens. In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis, with particular emphasis on specific molecular targets and epigenetic alterations in in vitro and in vivo human cancer animal models. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 17% |
| Argentina | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 158 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 26 | 16% |
| Student > Master | 22 | 14% |
| Researcher | 18 | 11% |
| Student > Ph. D. Student | 17 | 11% |
| Student > Postgraduate | 8 | 5% |
| Other | 27 | 17% |
| Unknown | 41 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 19% |
| Agricultural and Biological Sciences | 30 | 19% |
| Medicine and Dentistry | 13 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 6% |
| Nursing and Health Professions | 6 | 4% |
| Other | 17 | 11% |
| Unknown | 53 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 206. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2023.
All research outputs
#188,519
of 25,365,817 outputs
Outputs from Current Pharmacology Reports
#1
of 129 outputs
Outputs of similar age
#2,179
of 365,745 outputs
Outputs of similar age from Current Pharmacology Reports
#1
of 14 outputs
Altmetric has tracked 25,365,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 129 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.