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X Demographics
Mendeley readers
| Title |
The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference
|
|---|---|
| Published in |
CNS Neuroscience & Therapeutics, January 2018
|
| DOI | 10.1111/cns.12799 |
| Pubmed ID | |
| Authors |
Yong‐Mei Sun, Rong‐Xiang Chen, Zhi‐Fei Li, Sabine Spijker, Rong‐Wei Zhai, Shang‐Chuan Yang |
| Abstract |
The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine-induced CPP. Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 16% |
| Student > Master | 3 | 6% |
| Student > Doctoral Student | 2 | 4% |
| Student > Bachelor | 2 | 4% |
| Professor | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 29 | 59% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 8 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Psychology | 3 | 6% |
| Medicine and Dentistry | 3 | 6% |
| Nursing and Health Professions | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 29 | 59% |