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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antimicrobial Activity of Ibuprofen against Cystic Fibrosis-Associated Gram-Negative Pathogens
|
|---|---|
| Published in |
Antimicrobial Agents and Chemotherapy, February 2018
|
| DOI | 10.1128/aac.01574-17 |
| Pubmed ID | |
| Authors |
Parth N. Shah, Kimberly R. Marshall-Batty, Justin A. Smolen, Jasur A. Tagaev, Qingquan Chen, Christopher A. Rodesney, Henry H. Le, Vernita D. Gordon, David E. Greenberg, Carolyn L. Cannon |
| Abstract |
Clinical trials have demonstrated the benefits of ibuprofen therapy in cystic fibrosis (CF) patients, an effect that is currently attributed to ibuprofen's anti-inflammatory properties. Yet, a few previous reports demonstrate an antimicrobial activity of ibuprofen as well, although none investigate its direct effects on the pathogens found in the CF lung, which is the focus of this work. Determination of ibuprofen's in vitro antimicrobial activity against Pseudomonas aeruginosa and Burkholderia spp. strains through measurements of endpoint colony-forming units (CFU) and growth kinetics showed that ibuprofen reduces the growth rate and bacterial burden of tested strains in a dose-dependent fashion. In an in vitro Pseudomonas biofilm model, a reduction in the rate of biomass accumulation over 8-h of growth with ibuprofen treatment was observed. Next, an acute Pseudomonas pneumonia model was used to test this antimicrobial activity after oral delivery of ibuprofen. Following intranasal inoculation, ibuprofen-treated mice exhibited lower CFU counts and improved survival compared with control animals. Preliminary biodistribution studies performed after aerosolization of ibuprofen to mice demonstrated a rapid accumulation of ibuprofen in serum and minimum retention in lung tissue and bronchoalveolar lavage fluid. Therefore, ibuprofen-encapsulating polymeric nanoparticles (Ibu-NPs) were formulated to improve the pharmacokinetic profile. Ibu-NPs, formulated for aerosol delivery, inhibited the growth of P. aeruginosa in vitro and may provide a convenient dosing method. These results provide an additional explanation for the previously observed therapeutic effects of ibuprofen in CF patients, and further strengthen the argument for its use for these patients. |
X Demographics
The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 10 | 25% |
| United States | 5 | 13% |
| Greece | 1 | 3% |
| Georgia | 1 | 3% |
| Canada | 1 | 3% |
| Colombia | 1 | 3% |
| Argentina | 1 | 3% |
| Unknown | 20 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 75% |
| Scientists | 7 | 18% |
| Practitioners (doctors, other healthcare professionals) | 3 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 11% |
| Student > Bachelor | 9 | 11% |
| Researcher | 8 | 10% |
| Other | 7 | 8% |
| Student > Master | 7 | 8% |
| Other | 18 | 21% |
| Unknown | 26 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 10 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 12% |
| Medicine and Dentistry | 9 | 11% |
| Agricultural and Biological Sciences | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Other | 12 | 14% |
| Unknown | 29 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2018.
All research outputs
#1,054,865
of 25,382,440 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#326
of 15,580 outputs
Outputs of similar age
#23,667
of 343,867 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#8
of 223 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,580 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,867 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 223 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.