Title |
Bio-monitoring of Tissue Accumulation and Genotoxic Effect of Heavy Metals in Cyprinus carpio from River Kabul Khyber Pakhtunkhwa Pakistan
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Published in |
Bulletin of Environmental Contamination and Toxicology, January 2018
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DOI | 10.1007/s00128-017-2265-5 |
Pubmed ID | |
Authors |
Muhammad Siraj, Muhammad Khisroon, Ajmal Khan, Farrah Zaidi, Ahmad Ullah, Ghani Rahman |
Abstract |
The study explored (I) the concentration of heavy metals in water samples (II) their bioaccumulation in common carp Cyprinus carpio (III) and the subsequent genotoxicity in the selected organs of carp; from river Kabul, Khyber Pakhtunkhwa Pakistan. Except for Mercury (Hg) the water samples had all the heavy metals within permissible limits of recommended dietary allowance (RDA). Nonetheless a number of heavy metals (Zn, Ni, Cr, Cd, Pb and Hg) showed bioaccumulation at levels higher than permissible. Zinc (Zn) was the most while Cadmium (Cd) was the least accumulated metal in all tissue samples analyzed. The metal burden in different organs of C. carpio was in sequence of intestine > skin > liver > gills > muscle. The Comet assay established DNA damage in selected organs to be in accordance with metal burden; the most to least damage being in sequence of blood > intestine > skin > liver > gills > muscle. In conclusion assessment of DNA damage in the organs of C. carpio appears to be a useful bio-marker to evaluate genotoxic effects of heavy metal pollution. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 22% |
Student > Master | 4 | 17% |
Student > Bachelor | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Other | 1 | 4% |
Other | 4 | 17% |
Unknown | 6 | 26% |
Readers by discipline | Count | As % |
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Environmental Science | 4 | 17% |
Agricultural and Biological Sciences | 4 | 17% |
Chemistry | 3 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
Other | 2 | 9% |
Unknown | 6 | 26% |