| Title |
Brain Photobiomodulation Therapy: a Narrative Review
|
|---|---|
| Published in |
Molecular Neurobiology, January 2018
|
| DOI | 10.1007/s12035-017-0852-4 |
| Pubmed ID | |
| Authors |
Farzad Salehpour, Javad Mahmoudi, Farzin Kamari, Saeed Sadigh-Eteghad, Seyed Hossein Rasta, Michael R Hamblin |
| Abstract |
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. Red/NIR light is able to stimulate complex IV of the mitochondrial respiratory chain (cytochrome c oxidase) and increase ATP synthesis. Moreover, light absorption by ion channels results in release of Ca2+ and leads to activation of transcription factors and gene expression. Brain PBM therapy enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and antioxidant responses, as well as neurogenesis and synaptogenesis. Its therapeutic role in disorders such as dementia and Parkinson's disease, as well as to treat stroke, brain trauma, and depression has gained increasing interest. In the transcranial PBM approach, delivering a sufficient dose to achieve optimal stimulation is challenging due to exponential attenuation of light penetration in tissue. Alternative approaches such as intracranial and intranasal light delivery methods have been suggested to overcome this limitation. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of brain PBM therapy. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 13% |
| Czechia | 2 | 5% |
| Poland | 2 | 5% |
| United Kingdom | 2 | 5% |
| Canada | 1 | 3% |
| Argentina | 1 | 3% |
| Colombia | 1 | 3% |
| Unknown | 25 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 92% |
| Scientists | 1 | 3% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 378 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 378 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 47 | 12% |
| Student > Master | 42 | 11% |
| Student > Bachelor | 35 | 9% |
| Student > Ph. D. Student | 31 | 8% |
| Student > Doctoral Student | 24 | 6% |
| Other | 75 | 20% |
| Unknown | 124 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 12% |
| Neuroscience | 44 | 12% |
| Engineering | 32 | 8% |
| Biochemistry, Genetics and Molecular Biology | 20 | 5% |
| Nursing and Health Professions | 16 | 4% |
| Other | 78 | 21% |
| Unknown | 142 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2024.
All research outputs
#1,153,639
of 25,775,807 outputs
Outputs from Molecular Neurobiology
#79
of 4,016 outputs
Outputs of similar age
#26,248
of 453,537 outputs
Outputs of similar age from Molecular Neurobiology
#8
of 90 outputs
Altmetric has tracked 25,775,807 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,016 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,537 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.